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3.1 Regulation of immune cell function 3.1.1 T cell In RA, immune cells function abnormally, producing a large number of inflammatory factors, such as tumor necrosis factor (TNF)-, interleukin (IL)-6, and IL-17, which are distributed in clusters in the diseased joints, causing an inflammatory storm (5759)

For instance, adipose tissue has high levels of PPAR- expression, and the intestines, particularly the colon, also contain it (Auboeuf et al

*Correspondence: Raffaele Palmirotta [email protected] This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-B pathway, BMC Complementary and Alternative Medicine 16, 483490